Endocrine Abstracts

Objective: To evaluate the comparative effects of different glucocorticoid treatments on growth and sexual maturation in patients with congenital adrenal hyperplasia.Patients and methods: We conducted a retrospective observational cohort study in 78 patients (60 girls, 18 boys) diagnosed with congenital adrenal hyperplasia (CAH), followed-up for a period of 5 years. The majority had 21-hydroxylase deficiency (75 patients), 2 had 11-β hydroxylase def...

Case presentation: Mrs. S presented in an endocrine clinic for fatigue, weight loss, restlessness and goiter. She was obese with a BMI of 51 kg/mp, hypertensive and had a medium size, nontender goiter. Lab test revealed hyperglycaemia, suppressed TSH (<0.03mUI/L), on two separate occasions, mid-normal fT4 and T3. Thyroid ultrasound revealed multinodular goiter. A diagnosis of polynodular goiter with subclinical hyperthyroidism was made and patient was commenced on thiamazo...

Introduction: Matrix metalloproteinase-9 (MMP-9) is a zinc dependent proteolytic enzyme used by cells for degradation of the extracellular matrix during invasion and migration. There are only a few reports regarding the role played by MMP-9 in papillary thyroid carcinoma (PTC).Aim: To evaluate the association between MMP-9 secretion, reflected by preoperative serum levels and the histopathological features of thyroid tumors.Materia...

10% of patients with adrenal tumours have bilateral lesion.Objective: To evaluate clinical, imagistic and hormonal characteristics of bilateral adrenal tumours.Design and mehods: Retrospective series of 150 consecutive patients (104F, 46M) with bilateral adrenal tumours with maximal diameter of at least 1 cm, evaluated from 2001 to 2015 in a tertiary endocrinology clinic with clinical, hormonal and imagistic methods.<p class="a...

Background: The role of circulating Galectin-3 as a potential biomarker of malignancy in thyroid disease remains inconclusive. In a previous pilot study we reported a significant difference between serum Gal-3 levels in papillary thyroid carcinoma (PTC) patients and those with benign pathology, but no association with tumor aggressiveness.Aim: We measured serum Gal-3 levels in a larger series of patients submitted to thyroidectomy, in order to assess its...

Thyroid carcinoma is the most common endocrine malignancy and represents ~1% of all types of human cancer.Objective: As the molecular pathogenesis of thyroid cancer still remains to be clarified, the goal of our study was to find new molecular markers that could improve the diagnostics, follow-up protocols, treatment outcome, prognosis and the quality of life of differentiated thyroid cancer patients.Subjects and methods: Matched t...

Introduction: 17th European Congress of Endocrinology 2015. The skeleton health is reflected by the turnover markers as serum CrossLaps (CL=bone resorption), and serum osteocalcin (OC=bone formation), and by the calcium metabolism parameters (as ionic blood calcium, and, probably, by the 24-h urinary calcium=24-h ca). The peripheral serotonin might have intra-normal levels in patients with osteoporosis but yet represents a part of the complex equation related to the bone homeo...

Introduction: SOX2 is an early developmental transcription factor and a marker for pituitary progenitor cells.The study aimed to investigate if the pituitary adenomas with positive SOX2 immunoreactivity shows a different response to therapy as compared with controls.Patients and methods: We investigated 15 pituitary macroadenomas, eight with SOX2 immunoreactivity (SOX2+) and seven without (SOX2−) (controls); five were GH prod...

Background: Craniopharyngioma is a rare, mostly benign tumor of the central nervous system, generally associated with important morbidity.Aim: To study the clinical characteristics and treatment outcome in adult patients.Methods:: Adult patients diagnosed with craniopharyngioma between 1980 and 2012, followed-up in the Pituitary and Neuroendocrine Department of the ‘C.I.Parhon’ National Institute of Endocrinology in Bucha...

Objective: The analysis of the copy number variation of CYP21A2 gene in a cohort of 21-hydroxylase deficiency (21-OHD) pediatric patients in a tertiary referral center from Romania.Methods: A total of 24 patients (21 female and 3 male, 7:1 female to male sex ratio) with previously biochemically and clinically diagnosed 21-OHD were enrolled in this study from October 2020 to October 2021. The age at the diagnosis was 4.6±4.8 years (mean&#177...